1.原文連結：
https://reurl.cc/1x82r8
2.原文內容：
New Delhi: Oxford University’s COVID-19 vaccine failed to prevent the
monkeys from being infected with the novel coronavirus in trials, dashing the
UK's hopes of a safe and effective vaccine this year. The vaccine is among
the top candidates that are currently being tested on humans. But detailed
results from the animal trials showed that the ChAdOx1 nCoV-19 vaccine did
not stop rhesus macaque monkeys from contracting the virus, and it does not
stop the animals from spreading the infection to others as well.
The results, however, suggested that the vaccine may help reduce the severity
of the disease. The findings of the trial being carried out at the National
Institute of Health’s Rocky Mountain Laboratory in the US, were revealed by
Dr William Haseltine, a former Harvard Medical School professor. Writing in
an article in Forbes magazine which was published on Monday, Dr Haseltine
said that the Oxford vaccine data raises question as to why the trial was
still continuing on humans.
“All of the vaccinated monkeys treated with the Oxford vaccine became
infected when challenged as judged by recovery of virus genomic RNA from
nasal secretions. There was no difference in the amount of viral RNA detected
from this site in the vaccinated monkeys as compared to the unvaccinated
animals,” Dr Haseltine wrote.
For the trials, six rhesus macaque monkeys were given doses of ChAdOx1
nCoV-19 vaccine and they were exposed to the SARS-CoV-2 virus 28 days later.
The researchers also infected three non-vaccinated monkeys for comparison.
The researchers observed that all the vaccinated animals had SARS-CoV-19 in
their respiratory tracts, although they developed virus-specific neutralising
antibodies. The levels of virus shed by all the monkeys were also found to be
similar. However, the paper is yet to be peer-reviewed.
According to Jonathan Ball, professor of molecular virology at the University
of Nottingham, viral loads in the noses of vaccinated and unvaccinated
animals were identical is very significant, adding that if the same happened
in humans, the vaccine would not stop the virus from spreading it to others.
Ball said he believes that this finding should warrant an urgent re-appraisal
of the ongoing human trials of the ChAdOx1 vaccine, said a report in
Express.co.uk.
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以下為google 翻譯
新德里：牛津大學的COVID-19疫苗在試驗中未能阻止猴子被新型冠狀病毒感染，這打破了
英國今年對安全有效疫苗的希望。該疫苗是目前正在人類身上測試的頂級候選藥物之一。
但是動物實驗的詳細結果表明，ChAdOx1 nCoV-19疫苗不能阻止獼猴感染病毒，也不能阻
止動物將感染傳播給其他人。
但是，結果表明該疫苗可能有助於降低疾病的嚴重程度。哈佛大學醫學院前教授威廉·哈
塞爾廷（William Haseltine）博士透露了在美國國立衛生研究院落基山實驗室進行的試
驗結果。 Haseltine博士在周一發表的《福布斯》雜誌的一篇文章中寫道，牛津疫苗的數
據引發了人們對為何仍在繼續進行人類試驗的疑問。
“通過牛津疫苗處理的所有接種猴子在受到挑戰時都受到感染，這可以通過鼻分泌物中病
毒基因組RNA的回收來判斷。與未接種疫苗的動物相比，在接種猴子中從該位點檢測到的
病毒RNA的量沒有差異。”
在試驗中，給六隻恒河猴獼猴接種了ChAdOx1 nCoV-19疫苗，並在28天后暴露於
SARS-CoV-2病毒。研究人員還感染了三隻未接種疫苗的猴子進行比較。研究人員觀察到，
所有接種疫苗的動物都產生了病毒特異性中和抗體，儘管它們的呼吸道具有SARS-CoV-19
。還發現所有猴子散發的病毒水平相似。但是，該論文尚待同行評審。
諾丁漢大學分子病毒學教授喬納森·鮑爾（Jonathan Ball）說，接種疫苗和未接種疫苗
的動物鼻子中的病毒載量是非常重要的，並補充說，如果同樣的情況發生在人類身上，疫
苗也不會阻止病毒傳播。給別人。 Ball。Express.co.uk上的一篇報導說，鮑爾說，他相
信這一發現應該對目前正在進行的ChAdOx1疫苗的人體試驗進行重新評估。
3.心得/評論：
疫苗研發真的不容易，初期的設計就決定了成敗。檯面上一堆號稱的疫苗，恐怕
都有很高的失敗機率。如同之前專家說過的，可能永遠都不的有新冠疫苗。
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