禾伸堂在美癌症研究年會 發布CA102N新藥 - 股票
By George
at 2020-07-16T15:50
at 2020-07-16T15:50
Table of Contents
1.原文連結:
https://www.chinatimes.com/newspapers/20200715000435-260202?chdtv
2.原文內容:
禾伸堂在美癌症研究年會 發布CA102N新藥實驗
禾伸堂生技的大腸直腸癌抗癌新藥(簡稱:CA102N)於美國癌症研究協會年會會議(
AACR Virtual Annual Meeting Ⅱ)中,由安德森癌症中心(MD Anderson Cancer
Center)與禾伸堂生技共同發表CA102N透過抑制PI3K路徑及免疫調節機制抑制實驗結果。
目前實驗結果顯示,CA102N經由抑制腫瘤內PI3K相關路徑對CT26小鼠大腸癌腫瘤產生顯著
的生長抑制效果,同時可顯著降低腫瘤內發炎因子PGE2及PGI2,以及降低血液中IL-6與
MCP-1發炎細胞因子。另外,CA102N可降低腫瘤FOXP3+ T-regulatory細胞並且提高CD8
+ T-cell,藉由上述降低發炎因子及免疫調節作用,進一步提高其抑制腫瘤生長之能力
。
禾伸堂指出,CA102N是利用透明質酸作為抗癌藥物載體的標靶治療藥物,藉由透明質酸共
軛鍵結藥物技術,將透明質酸與癌細胞表面的特徵接受器Cluster of differentiation
44(CD44)產生系統性的交互作用後,讓透明質酸鍵結之藥物遞送到癌細胞內部,CA102N
其抑癌機轉為抑制PI3K/Akt/mTOR相關路徑,並誘導細胞凋亡與抑制血管新生,具免疫
治療潛力,目前已在美國進行第一期人體臨床實驗,未來不排除還可擴及其它癌症的治療
。
3.心得/評論:
就在新藥股大幅回檔的情況下
今天禾伸堂呈現貼息
如果能早一點搭上順風車的話
--
https://www.chinatimes.com/newspapers/20200715000435-260202?chdtv
2.原文內容:
禾伸堂在美癌症研究年會 發布CA102N新藥實驗
禾伸堂生技的大腸直腸癌抗癌新藥(簡稱:CA102N)於美國癌症研究協會年會會議(
AACR Virtual Annual Meeting Ⅱ)中,由安德森癌症中心(MD Anderson Cancer
Center)與禾伸堂生技共同發表CA102N透過抑制PI3K路徑及免疫調節機制抑制實驗結果。
目前實驗結果顯示,CA102N經由抑制腫瘤內PI3K相關路徑對CT26小鼠大腸癌腫瘤產生顯著
的生長抑制效果,同時可顯著降低腫瘤內發炎因子PGE2及PGI2,以及降低血液中IL-6與
MCP-1發炎細胞因子。另外,CA102N可降低腫瘤FOXP3+ T-regulatory細胞並且提高CD8
+ T-cell,藉由上述降低發炎因子及免疫調節作用,進一步提高其抑制腫瘤生長之能力
。
禾伸堂指出,CA102N是利用透明質酸作為抗癌藥物載體的標靶治療藥物,藉由透明質酸共
軛鍵結藥物技術,將透明質酸與癌細胞表面的特徵接受器Cluster of differentiation
44(CD44)產生系統性的交互作用後,讓透明質酸鍵結之藥物遞送到癌細胞內部,CA102N
其抑癌機轉為抑制PI3K/Akt/mTOR相關路徑,並誘導細胞凋亡與抑制血管新生,具免疫
治療潛力,目前已在美國進行第一期人體臨床實驗,未來不排除還可擴及其它癌症的治療
。
3.心得/評論:
就在新藥股大幅回檔的情況下
今天禾伸堂呈現貼息
如果能早一點搭上順風車的話
--
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