淺談新藥 - 股票
By John
at 2020-07-11T14:11
at 2020-07-11T14:11
Table of Contents
近期看著新藥一窩蜂的熱
好像只要跟藥有關通通都是搖錢樹一般
然而大部分的人只是想跟風一波
對新藥本身卻一知半解
不知其中風險、技術就一直無腦多
也有些人不知道是有意還是無意的鼓吹夢想
說來也弔詭
一邊說著未來美好夢想的同時
當討論起成功率、市場時
又會改口說反正只是衝一波,又沒有要真的放到最後,不管成功失敗早就口袋滿滿了
如果你真的認為會成功,為什麼不放到夢想實現,豈不噴飛
如果你自己也不認為會成功,那為什麼要向別人鼓吹你自己都不相信的夢想
擺明說我就是只想炒一波很難嗎?
嘛~大概在5.6年前也有過一波生技熱
然後...賺的人賠的人都只有一個印象,台灣生技就只是炒作起來的(明明還是很有料的)
不勝唏噓
上面只是感嘆
下面來講點實在的
整篇重點只有這一個表
https://i.imgur.com/BNjeplR.jpg
只要是你看得到的新藥,幾乎100%都會進一期
不然花錢做臨床前研究幹嘛?沒用的早在實驗室就胎死腹中了,你根本不會看到
因此申請一期、進入一期,是基本中的基本
所以這個表是這樣看的
phase 1-2,從一期往二期做下去的比例(就是一期成功+做二期的意思啦)
phase 2-3是二期成功+往下做三期,這邊需要注意,二期成功有時不一定會做三期
同理,phase 3-BLA(NDA)就是三期成功、申請藥證
BLA-Approval就是拿到藥證
NME跟non-NME的區別我不是非常確定,因此有錯歡迎指正
NME就是一般的小分子新藥
Biologic為蛋白質藥、單抗藥那類的
non-NME我的理解是505B2那個途徑的,新劑型、新給藥方式、新適應症等的新藥
Vaccine是疫苗
所以當你看到一個小分子新藥
臨床前或是正在一期的
他最終成功的機率是6.1%
開始做二期的(一期成功),他已經贏過了那些第一關被淘汰的40%
正在做三期、等解盲的,最終核准上市的成功率是38%(48.7%x78%),即便提出藥證申請還
是有一定比例是失敗的(22%)
這裡講的只是比例(成功率)
如果是無腦多的話,看到這就好了
但如果你想要提高勝率
怎麼能不去研究這間公司葫蘆裡賣的是什麼藥?
是不是真的有前景,結果夠不夠好,跟其他競爭者比起來的優勢是什麼,市場多大等等
提高你選到那6.1%的機率,而不是另外失敗的94%
在做過功課認為這藥確實有潛力後
通常二期有好結果、三期做個幾年是正常的,也不用急著在一開始就衝進去,那時可能剛
漲過一波
臨床試驗都會有預期結束時間
每年公司也都會更新一下進度
大概在預期解盲前的半年~一年內找個好時機(低點)
先進場等了也是個好方法
只要三期做下去,成功率至少5成
(但反過來說也有2.5~5成的機率是賭錯的XD)
再加上如果你有做過功課,你的勝率會高過5成
然後就是等好消息
這也是為什麼"正常情況"下
二期成功才會有人關注,要賭至少勝率高些嘛
三期要做好幾年,總不會股價維持好幾年都在高點
我相信大部分的人也不會想放著等好幾年
所以三期中後才會有熱度的原因就在這
當然現在群魔亂舞的情況下什麼都能炒
不計風險的話
什麼臨床前研究顯示啊,申請一期、申請二期(等同一期成功)的
通通都在炒
不論哪種形式的新藥,二期往三期是失敗率最高的階段
因為三期太花時間、太花錢,是否做三期是最大的檻(即便二期成功也不一定會做三期,
一定要確實有潛力)
這篇並不是說三期前都是垃圾
也不是說三期前都不會漲、不會炒
有心都可以炒
有炒都可以漲
而是在說風險問題(成功率)
有這個認知後,進不進賭場、是漲是跌都是個人的選擇
補充一下
這篇強調的是如果無腦多,就是單純賭整體成功率
但如果你做過功課,選擇有潛力的新藥,你能提高你的勝率
我無意對個別公司分析他的藥好/不好
更無意探討他的股票是漲是跌
股價我真的猜不透,不然我早就退休了XD
稍早有人回說基期夠低都買爆
也不是不行,但風險自然就是高
舉例來說
https://i.imgur.com/bXiJiQE.jpg
這檔(興櫃)在2011年6~10月二期解盲成功(年代久遠查不到確切日期)
股價有高有低,但並無明顯的拉抬
https://i.imgur.com/mbstLG1.jpg
這檔則是2019/04/09新聞出來說二期解盲成功
好像有拉,但又不是很多且隨即被出貨
這還是賭中那25%成功的範例
好不容易4次中1次,漲的卻還不夠補另外3次失敗賠的部分
所以我真的不知道在二期就先進場等在那的用意是?
不賣關子
第一張圖是on101二期解盲成功
第二張圖是太景C肝藥二期解盲成功
除了最近群魔亂舞外,在二期成功之前就賭下去的勝率真的不是很高
當然也沒說絕對沒搞頭
股價高高低低本來就能做波段
風險自己拿捏好就行
--
好像只要跟藥有關通通都是搖錢樹一般
然而大部分的人只是想跟風一波
對新藥本身卻一知半解
不知其中風險、技術就一直無腦多
也有些人不知道是有意還是無意的鼓吹夢想
說來也弔詭
一邊說著未來美好夢想的同時
當討論起成功率、市場時
又會改口說反正只是衝一波,又沒有要真的放到最後,不管成功失敗早就口袋滿滿了
如果你真的認為會成功,為什麼不放到夢想實現,豈不噴飛
如果你自己也不認為會成功,那為什麼要向別人鼓吹你自己都不相信的夢想
擺明說我就是只想炒一波很難嗎?
嘛~大概在5.6年前也有過一波生技熱
然後...賺的人賠的人都只有一個印象,台灣生技就只是炒作起來的(明明還是很有料的)
不勝唏噓
上面只是感嘆
下面來講點實在的
整篇重點只有這一個表
https://i.imgur.com/BNjeplR.jpg
只要是你看得到的新藥,幾乎100%都會進一期
不然花錢做臨床前研究幹嘛?沒用的早在實驗室就胎死腹中了,你根本不會看到
因此申請一期、進入一期,是基本中的基本
所以這個表是這樣看的
phase 1-2,從一期往二期做下去的比例(就是一期成功+做二期的意思啦)
phase 2-3是二期成功+往下做三期,這邊需要注意,二期成功有時不一定會做三期
同理,phase 3-BLA(NDA)就是三期成功、申請藥證
BLA-Approval就是拿到藥證
NME跟non-NME的區別我不是非常確定,因此有錯歡迎指正
NME就是一般的小分子新藥
Biologic為蛋白質藥、單抗藥那類的
non-NME我的理解是505B2那個途徑的,新劑型、新給藥方式、新適應症等的新藥
Vaccine是疫苗
所以當你看到一個小分子新藥
臨床前或是正在一期的
他最終成功的機率是6.1%
開始做二期的(一期成功),他已經贏過了那些第一關被淘汰的40%
正在做三期、等解盲的,最終核准上市的成功率是38%(48.7%x78%),即便提出藥證申請還
是有一定比例是失敗的(22%)
這裡講的只是比例(成功率)
如果是無腦多的話,看到這就好了
但如果你想要提高勝率
怎麼能不去研究這間公司葫蘆裡賣的是什麼藥?
是不是真的有前景,結果夠不夠好,跟其他競爭者比起來的優勢是什麼,市場多大等等
提高你選到那6.1%的機率,而不是另外失敗的94%
在做過功課認為這藥確實有潛力後
通常二期有好結果、三期做個幾年是正常的,也不用急著在一開始就衝進去,那時可能剛
漲過一波
臨床試驗都會有預期結束時間
每年公司也都會更新一下進度
大概在預期解盲前的半年~一年內找個好時機(低點)
先進場等了也是個好方法
只要三期做下去,成功率至少5成
(但反過來說也有2.5~5成的機率是賭錯的XD)
再加上如果你有做過功課,你的勝率會高過5成
然後就是等好消息
這也是為什麼"正常情況"下
二期成功才會有人關注,要賭至少勝率高些嘛
三期要做好幾年,總不會股價維持好幾年都在高點
我相信大部分的人也不會想放著等好幾年
所以三期中後才會有熱度的原因就在這
當然現在群魔亂舞的情況下什麼都能炒
不計風險的話
什麼臨床前研究顯示啊,申請一期、申請二期(等同一期成功)的
通通都在炒
不論哪種形式的新藥,二期往三期是失敗率最高的階段
因為三期太花時間、太花錢,是否做三期是最大的檻(即便二期成功也不一定會做三期,
一定要確實有潛力)
這篇並不是說三期前都是垃圾
也不是說三期前都不會漲、不會炒
有心都可以炒
有炒都可以漲
而是在說風險問題(成功率)
有這個認知後,進不進賭場、是漲是跌都是個人的選擇
補充一下
這篇強調的是如果無腦多,就是單純賭整體成功率
但如果你做過功課,選擇有潛力的新藥,你能提高你的勝率
我無意對個別公司分析他的藥好/不好
更無意探討他的股票是漲是跌
股價我真的猜不透,不然我早就退休了XD
稍早有人回說基期夠低都買爆
也不是不行,但風險自然就是高
舉例來說
https://i.imgur.com/bXiJiQE.jpg
這檔(興櫃)在2011年6~10月二期解盲成功(年代久遠查不到確切日期)
股價有高有低,但並無明顯的拉抬
https://i.imgur.com/mbstLG1.jpg
這檔則是2019/04/09新聞出來說二期解盲成功
好像有拉,但又不是很多且隨即被出貨
這還是賭中那25%成功的範例
好不容易4次中1次,漲的卻還不夠補另外3次失敗賠的部分
所以我真的不知道在二期就先進場等在那的用意是?
不賣關子
第一張圖是on101二期解盲成功
第二張圖是太景C肝藥二期解盲成功
除了最近群魔亂舞外,在二期成功之前就賭下去的勝率真的不是很高
當然也沒說絕對沒搞頭
股價高高低低本來就能做波段
風險自己拿捏好就行
--
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at 2021-03-27T14:47
By Xanthe
at 2021-04-01T08:48
at 2021-04-01T08:48
By Kumar
at 2021-04-03T05:45
at 2021-04-03T05:45
By Daph Bay
at 2021-04-03T17:35
at 2021-04-03T17:35
By Annie
at 2021-04-04T05:33
at 2021-04-04T05:33
By Sierra Rose
at 2021-04-06T02:14
at 2021-04-06T02:14
By Daph Bay
at 2021-04-09T01:23
at 2021-04-09T01:23
By Steve
at 2021-04-13T23:42
at 2021-04-13T23:42
By Tristan Cohan
at 2021-04-14T18:33
at 2021-04-14T18:33
By Andy
at 2021-04-15T21:05
at 2021-04-15T21:05
By Linda
at 2021-04-20T07:43
at 2021-04-20T07:43
By Isla
at 2021-04-21T09:11
at 2021-04-21T09:11
By David
at 2021-04-24T04:52
at 2021-04-24T04:52
By Dorothy
at 2021-04-28T08:08
at 2021-04-28T08:08
By Oscar
at 2021-05-01T10:08
at 2021-05-01T10:08
By Wallis
at 2021-05-03T07:29
at 2021-05-03T07:29
By Charlotte
at 2021-05-04T05:10
at 2021-05-04T05:10
By Valerie
at 2021-05-08T08:16
at 2021-05-08T08:16
By Hedda
at 2021-05-11T16:49
at 2021-05-11T16:49
By Gilbert
at 2021-05-14T18:43
at 2021-05-14T18:43
By Oscar
at 2021-05-17T14:40
at 2021-05-17T14:40
By Zenobia
at 2021-05-20T03:39
at 2021-05-20T03:39
By Agnes
at 2021-05-24T11:24
at 2021-05-24T11:24
By Megan
at 2021-05-25T20:50
at 2021-05-25T20:50
By Charlotte
at 2021-05-26T08:50
at 2021-05-26T08:50
By Iris
at 2021-05-30T05:07
at 2021-05-30T05:07
By Ivy
at 2021-05-30T17:35
at 2021-05-30T17:35
By Freda
at 2021-05-30T21:23
at 2021-05-30T21:23
By Hedwig
at 2021-06-04T15:59
at 2021-06-04T15:59
By Delia
at 2021-06-08T22:00
at 2021-06-08T22:00
By Emily
at 2021-06-09T23:35
at 2021-06-09T23:35
By Elizabeth
at 2021-06-12T09:34
at 2021-06-12T09:34
By Hardy
at 2021-06-14T15:15
at 2021-06-14T15:15
By Charlotte
at 2021-06-16T11:19
at 2021-06-16T11:19
By Rosalind
at 2021-06-17T10:01
at 2021-06-17T10:01
By Dora
at 2021-06-21T07:29
at 2021-06-21T07:29
By Eartha
at 2021-06-22T04:35
at 2021-06-22T04:35
By Una
at 2021-06-25T07:38
at 2021-06-25T07:38
By Emily
at 2021-06-29T06:41
at 2021-06-29T06:41
By Jack
at 2021-06-30T10:28
at 2021-06-30T10:28
By Noah
at 2021-07-04T09:20
at 2021-07-04T09:20
By John
at 2021-07-05T06:49
at 2021-07-05T06:49
By Leila
at 2021-07-07T23:51
at 2021-07-07T23:51
By Steve
at 2021-07-09T20:23
at 2021-07-09T20:23
By Hedwig
at 2021-07-12T04:49
at 2021-07-12T04:49
By Jacky
at 2021-07-15T07:37
at 2021-07-15T07:37
By Skylar DavisLinda
at 2021-07-18T19:33
at 2021-07-18T19:33
By Robert
at 2021-07-21T08:42
at 2021-07-21T08:42
By Odelette
at 2021-07-21T13:04
at 2021-07-21T13:04
By Audriana
at 2021-07-21T18:10
at 2021-07-21T18:10
By Ophelia
at 2021-07-25T18:11
at 2021-07-25T18:11
By Suhail Hany
at 2021-07-28T16:53
at 2021-07-28T16:53
By Candice
at 2021-07-31T03:15
at 2021-07-31T03:15
By Thomas
at 2021-08-03T09:49
at 2021-08-03T09:49
By Belly
at 2021-08-05T21:10
at 2021-08-05T21:10
By Susan
at 2021-08-07T21:39
at 2021-08-07T21:39
By Damian
at 2021-08-12T16:34
at 2021-08-12T16:34
By Lauren
at 2021-08-16T08:34
at 2021-08-16T08:34
By Thomas
at 2021-08-18T03:12
at 2021-08-18T03:12
By Ophelia
at 2021-08-18T08:00
at 2021-08-18T08:00
By Suhail Hany
at 2021-08-21T21:37
at 2021-08-21T21:37
By Hazel
at 2021-08-22T02:14
at 2021-08-22T02:14
By Hardy
at 2021-08-23T17:12
at 2021-08-23T17:12
By Lily
at 2021-08-26T18:40
at 2021-08-26T18:40
By Iris
at 2021-08-28T06:42
at 2021-08-28T06:42
By Victoria
at 2021-08-30T05:46
at 2021-08-30T05:46
By Irma
at 2021-09-01T19:09
at 2021-09-01T19:09
By Xanthe
at 2021-09-05T08:44
at 2021-09-05T08:44
By Victoria
at 2021-09-06T21:00
at 2021-09-06T21:00
By Gary
at 2021-09-09T20:43
at 2021-09-09T20:43
By Zanna
at 2021-09-13T08:39
at 2021-09-13T08:39
By Tracy
at 2021-09-15T20:51
at 2021-09-15T20:51
By Charlie
at 2021-09-17T22:27
at 2021-09-17T22:27
By Rachel
at 2021-09-19T18:12
at 2021-09-19T18:12
By Regina
at 2021-09-22T10:05
at 2021-09-22T10:05
By Oscar
at 2021-09-23T03:02
at 2021-09-23T03:02
By Kyle
at 2021-09-26T14:43
at 2021-09-26T14:43
By Oscar
at 2021-09-30T00:19
at 2021-09-30T00:19
By Edwina
at 2021-10-03T21:26
at 2021-10-03T21:26
By Franklin
at 2021-10-08T13:16
at 2021-10-08T13:16
By Caitlin
at 2021-10-11T20:18
at 2021-10-11T20:18
By Tracy
at 2021-10-14T14:29
at 2021-10-14T14:29
By Tracy
at 2021-10-15T05:41
at 2021-10-15T05:41
By Hedy
at 2021-10-16T17:44
at 2021-10-16T17:44
By Damian
at 2021-10-17T05:18
at 2021-10-17T05:18
By Quanna
at 2021-10-21T12:40
at 2021-10-21T12:40
By Lily
at 2021-10-23T09:30
at 2021-10-23T09:30
By Thomas
at 2021-10-23T19:42
at 2021-10-23T19:42
By Hedwig
at 2021-10-25T21:34
at 2021-10-25T21:34
By Lucy
at 2021-10-30T07:11
at 2021-10-30T07:11
By Lucy
at 2021-11-02T00:26
at 2021-11-02T00:26
By Elizabeth
at 2021-11-04T17:30
at 2021-11-04T17:30
By Kristin
at 2021-11-05T06:41
at 2021-11-05T06:41
By Sarah
at 2021-11-06T03:09
at 2021-11-06T03:09
By Odelette
at 2021-11-06T10:38
at 2021-11-06T10:38
By Thomas
at 2021-11-08T01:58
at 2021-11-08T01:58
By Mason
at 2021-11-11T19:38
at 2021-11-11T19:38
By Daph Bay
at 2021-11-13T05:50
at 2021-11-13T05:50
By Frederic
at 2021-11-16T22:31
at 2021-11-16T22:31
By Eartha
at 2021-11-19T07:08
at 2021-11-19T07:08
By Zora
at 2021-11-21T02:08
at 2021-11-21T02:08
By Ophelia
at 2021-11-22T09:29
at 2021-11-22T09:29
By Valerie
at 2021-11-23T07:12
at 2021-11-23T07:12
By Olivia
at 2021-11-23T19:05
at 2021-11-23T19:05
By Cara
at 2021-11-27T15:31
at 2021-11-27T15:31
By Donna
at 2021-11-30T13:08
at 2021-11-30T13:08
By Elma
at 2021-12-01T02:40
at 2021-12-01T02:40
By Carol
at 2021-12-01T20:17
at 2021-12-01T20:17
By Frederic
at 2021-12-02T06:31
at 2021-12-02T06:31
By Annie
at 2021-12-05T19:46
at 2021-12-05T19:46
By Mia
at 2021-12-06T00:35
at 2021-12-06T00:35
By Mia
at 2021-12-08T04:32
at 2021-12-08T04:32
By Carol
at 2021-12-09T00:57
at 2021-12-09T00:57
By Sandy
at 2021-12-12T08:32
at 2021-12-12T08:32
By William
at 2021-12-13T13:28
at 2021-12-13T13:28
By Freda
at 2021-12-17T08:38
at 2021-12-17T08:38
By Jacob
at 2021-12-20T08:48
at 2021-12-20T08:48
By Caitlin
at 2021-12-24T07:17
at 2021-12-24T07:17
By Lucy
at 2021-12-26T03:21
at 2021-12-26T03:21
By Valerie
at 2021-12-29T05:28
at 2021-12-29T05:28
By Necoo
at 2021-12-31T08:05
at 2021-12-31T08:05
By Olive
at 2022-01-02T22:38
at 2022-01-02T22:38
By Faithe
at 2022-01-05T15:09
at 2022-01-05T15:09
By Andy
at 2022-01-07T15:12
at 2022-01-07T15:12
By Xanthe
at 2022-01-09T20:00
at 2022-01-09T20:00
By Dora
at 2022-01-14T13:28
at 2022-01-14T13:28
By Connor
at 2022-01-18T22:38
at 2022-01-18T22:38
By Kyle
at 2022-01-22T00:16
at 2022-01-22T00:16
By Genevieve
at 2022-01-26T11:21
at 2022-01-26T11:21
By Elizabeth
at 2022-01-28T03:08
at 2022-01-28T03:08
By Regina
at 2022-02-01T14:36
at 2022-02-01T14:36
By Yedda
at 2022-02-05T17:04
at 2022-02-05T17:04
By Olive
at 2022-02-10T06:49
at 2022-02-10T06:49
By Jake
at 2022-02-11T00:02
at 2022-02-11T00:02
By Zanna
at 2022-02-11T08:14
at 2022-02-11T08:14
By Joe
at 2022-02-12T20:24
at 2022-02-12T20:24
By Frederica
at 2022-02-14T14:00
at 2022-02-14T14:00
By Hedda
at 2022-02-16T18:54
at 2022-02-16T18:54
By Daniel
at 2022-02-20T12:12
at 2022-02-20T12:12
By Christine
at 2022-02-22T19:23
at 2022-02-22T19:23
By Kumar
at 2022-02-24T06:11
at 2022-02-24T06:11
By Odelette
at 2022-02-24T10:24
at 2022-02-24T10:24
By Oscar
at 2022-02-27T02:20
at 2022-02-27T02:20
By Blanche
at 2022-03-02T20:59
at 2022-03-02T20:59
By Yuri
at 2022-03-03T01:35
at 2022-03-03T01:35
By Dinah
at 2022-03-03T13:09
at 2022-03-03T13:09
By Puput
at 2022-03-04T09:38
at 2022-03-04T09:38
By Hardy
at 2022-03-06T14:33
at 2022-03-06T14:33
By Tracy
at 2022-03-10T01:51
at 2022-03-10T01:51
By Damian
at 2022-03-14T08:32
at 2022-03-14T08:32
By Eden
at 2022-03-14T16:29
at 2022-03-14T16:29
By Adele
at 2022-03-18T23:11
at 2022-03-18T23:11
By Sarah
at 2022-03-20T05:13
at 2022-03-20T05:13
By Yuri
at 2022-03-25T03:53
at 2022-03-25T03:53
By Christine
at 2022-03-26T12:15
at 2022-03-26T12:15
By Victoria
at 2022-03-30T15:11
at 2022-03-30T15:11
By Hamiltion
at 2022-03-30T23:45
at 2022-03-30T23:45
By Iris
at 2022-03-31T14:10
at 2022-03-31T14:10
By Bethany
at 2022-04-03T16:30
at 2022-04-03T16:30
By Tom
at 2022-04-04T19:16
at 2022-04-04T19:16
By Irma
at 2022-04-07T12:50
at 2022-04-07T12:50
By Olivia
at 2022-04-08T04:22
at 2022-04-08T04:22
By Tristan Cohan
at 2022-04-09T18:37
at 2022-04-09T18:37
By Jack
at 2022-04-10T08:22
at 2022-04-10T08:22
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at 2022-04-10T15:30
at 2022-04-10T15:30
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at 2022-04-15T14:21
at 2022-04-15T14:21
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at 2022-04-20T14:12
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at 2022-04-21T17:01
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at 2022-04-25T06:20
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at 2022-04-27T03:20
at 2022-04-27T03:20
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at 2022-04-30T12:45
at 2022-04-30T12:45
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at 2022-04-30T23:20
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at 2022-05-01T10:23
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at 2022-05-03T23:38
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at 2022-05-05T11:43
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at 2022-05-06T10:34
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at 2022-05-07T05:09
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at 2022-05-11T11:10
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at 2022-05-21T12:56
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at 2022-05-28T00:40
at 2022-05-28T00:40
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at 2022-05-30T10:04
at 2022-05-30T10:04
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at 2022-05-30T21:00
at 2022-05-30T21:00
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at 2022-05-31T13:52
at 2022-05-31T13:52
By Daph Bay
at 2022-06-03T17:28
at 2022-06-03T17:28
By Rachel
at 2022-06-08T14:03
at 2022-06-08T14:03
By Gilbert
at 2022-06-08T23:08
at 2022-06-08T23:08
By Victoria
at 2022-06-09T15:55
at 2022-06-09T15:55
By Sarah
at 2022-06-11T04:55
at 2022-06-11T04:55
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at 2022-06-15T14:42
at 2022-06-15T14:42
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at 2022-06-20T05:16
at 2022-06-20T05:16
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at 2022-06-21T02:41
at 2022-06-21T02:41
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at 2022-06-21T12:27
at 2022-06-21T12:27
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at 2022-06-22T17:44
at 2022-06-22T17:44
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at 2022-06-24T02:52
at 2022-06-24T02:52
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at 2022-06-26T10:09
at 2022-06-26T10:09
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at 2022-06-28T15:41
at 2022-06-28T15:41
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at 2022-07-03T12:57
at 2022-07-03T12:57
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at 2022-07-04T01:33
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at 2022-07-08T00:47
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at 2022-07-12T17:06
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at 2022-07-13T13:21
at 2022-07-13T13:21
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at 2022-07-15T20:24
at 2022-07-15T20:24
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at 2022-07-16T11:51
at 2022-07-16T11:51
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at 2022-07-20T10:35
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at 2022-07-22T04:38
at 2022-07-22T04:38
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at 2022-07-24T20:36
at 2022-07-24T20:36
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at 2022-07-28T14:13
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