合一FB704A美國第一期 臨床試驗結果 - 股票
By Jacky
at 2020-08-17T22:06
at 2020-08-17T22:06
Table of Contents
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1.原文連結:https://reurl.cc/ygZmyE
※過長無法點擊者必須縮網址
2.原文內容:
1.產品內容:Anti-IL6全人單株抗體新藥FB704A
2.產品量產日期:NA
3.對公司財務、業務之影響:
(1)研發新藥名稱或代號:FB704A。
(2)用途:中和IL6之全人源單株抗體新藥,治療因IL6引起之相關疾病。
臨床試驗資訊網址:https://clinicaltrials.gov/ct2/show/NCT03890302
(3)預計進行之所有研發階段:探索性二期臨床試驗/二期臨床試驗/三期臨床試驗及
新藥查驗登記。
(4)目前進行中之研發階段:第一期臨床試驗。(Ia+Ib)
A.各期人體臨床試驗(含期中分析)結果:
(A)臨床試驗設計介紹
a.試驗計畫名稱:評估FB704A單次和多次遞增劑量的安全性,耐受性,藥
物動力學、和臨床活性之第一期、隨機,安慰劑對照,雙盲臨床試驗。
b.試驗目的:於美國執行單一中心、隨機分派、對照組控制之一期臨床試
驗,評估FB704A針對健康受試者及類風濕性關節炎病人之安全性、耐受
性、藥物動力及臨床活性。
c.試驗階段分級:第一期臨床試驗。
d.藥品名稱:FB704A。
e.宣稱適應症:類風濕性關節炎。
f.評估指標
(a)主要評估指標:FB704A之安全性、耐受性
(b)次要評估指標:藥物動力學 (Pharmacokinetics;PK)、免疫原性
(Immunogenicity)、生物標記 (包括:IL-6、CRP及ESR)、關節炎活
動度(DAS28-CRP, TJC 及 SJC)。
g.試驗計畫受試者收納人數:健康受試者25人,類風濕性關節炎患者最多
16人。
(B)主要及次要評估指標之統計結果及統計上之意義:
本公司抗IL6抗體新藥FB704A一期臨床試驗,共收納健康受試者25人,類
風濕性關節炎患者6人,各項臨床試驗指標結果如下:
a.主要評估指標:FB704A之安全性、耐受性
(a)試驗結果顯示,在使用至8 mg/kg的最高劑量下,FB704A無論在健康
受試者或類風濕性關節炎病患,皆具有良好的安全性與耐受性。在
納入試驗的25位健康受試者與6位類風濕關節炎受試者中,皆無藥物
相關的嚴重不良反應(SAE)發生。所有不良反應(AEs)皆為二級以下,
並且在試驗結束後皆已緩解。主要藥物相關不良反應包括白血球與中
性顆粒球降低,為IL6抗體藥物常見之不良反應。
(b)所有受試者的臨床實驗室檢查(血液學、凝血功能、血清化學、肝功
能及尿液檢查)、生命體徵測量(收縮壓、舒張壓、心跳速率、呼吸
速率及口溫)、12導聯心電圖、心電遙測和理學檢查結果,皆顯示
FB704A未造成不良影響。
(c)FB704A的最大耐受劑量 (MTD)為 > 8 mg/kg。
b.次要評估指標:
(a)藥物動力學 (Pharmacokinetics;PK):
在健康受試者,分別靜脈輸注投予一劑0.5, 2, 4, 8 mg/kg的FB704A
後,最高血中藥物濃度(Cmax)、時間零至最終採血點時間之曲線下總
面積(AUC0-t)與時間零至無限大之曲線下總面積(AUC0-∞),皆隨劑
量增加而增加,且生體半衰期長達約14天,結果顯示FB704A具有良好
的藥動學特性。
此外,類風濕性關節炎病人每兩周投予一劑2 mg/kg的FB704A,連續
投予4劑的結果顯示,與健康受試者具有相似的藥動學特性,且無顯
著蓄積性。上述結果有助於未來二期臨床試驗之設計及規劃。
(b)免疫原性(immunogenicity):
FB704A給藥組皆未產生FB704A的自體抗體,初步顯示FB704A的低免疫
原性。
(c)生物標記:
(i)IL6:RA病人給予FB704A前血液中的IL6濃度為255.98±504.89pg/ml
,而給予四劑FB704A後,血中IL6濃度增加為1205.38±437.16pg/ml
,顯示FB704A有效結合血中IL6,使IL6被FB704A捕獲而累積於血
液中。
(ii)CRP: CRP為發炎反應以及類風濕性關節炎的重要指標,病患給予
FB704A後平均CRP數值下降60.9%,高於安慰劑組的35.7%,初步
驗證FB704A於RA病人產生的藥效。
(iii)ESR:ESR為紅血球沉降速率,本試驗尚未觀察到變化趨勢。
(d)關節炎活動度 (DAS28-CRP,TJC及SJC):
由於受試病患族群少且治療時間較短,本試驗尚未觀察到變化趨勢。
(C)單一臨床試驗結果,並不足以充分反映未來新藥開發上市之成敗,投資人
應審慎判斷謹慎投資。
B.未通過目的事業主管機關許可者,公司所面臨之風險及因應措施:不適用。
C.已通過目的事業主管機關許可者,未來經營方向:不適用。
D.已投入之累積研發費用:考量未來市場行銷策略,為保障公司及投資人權益,
故不予公開揭露。
(5)將再進行之下一研發階段:探索性二期臨床試驗/二期臨床試驗
A.預計完成時間:依據一期臨床試驗之結果,積極設計探索性二期臨床試驗,預計
2021年可完成此試驗。
B.預計應負擔之義務:不適用。
(6)市場現況:
FB704A完成一期臨床試驗,除獲得完整藥動學參數外,並初步驗證其安全性與人體
藥理活性,由於IL6相關疾病的適應症廣泛,本公司正積極評估以下具市場潛力的
適應症:
A.全身性硬化症及其肺部纖維化機制與IL-6作用相關,全球約有2.7 million病人
,2026年全球藥物市場預估為38億美金(globe newswire),過往多透過免疫調
節、類固醇與抗發炎等藥物來減少全身性硬化症的惡化,新上市藥物也僅能改
善肺功能,未能有效阻止皮膚症狀的惡化,目前全身性硬化症未有生物製劑上
市。
B.氣喘藥物全球市場2027年將達到260.1億美金(globe newswire) ,病人數上看
33.4 million,嚴重氣喘族群雖僅佔10% 氣喘病人數,卻佔據了50%以上的醫療
花費,其中復發率高且難以控制的嚴重嗜中球性氣喘 (neutrophilic asthma)
,致病機轉與IL-6相關,該病症目前已上市藥物皆無法有效控制,為目前未被
滿足的醫療需求。
4.其他應敘明事項:
(1)依據財團法人中華民國證券櫃檯買賣中心之「上(興)櫃公司重大訊息發布應注意事
項參考問答集」第二項規範:「新藥研發公司取得各期人體臨床試驗評估指標之統
計結果時,即時發布重大訊息。
(2)新藥開發時程長、投入經費高且並未保證一定能成功,此等可能使投資面臨風險,
投資人應審慎判斷謹慎投資。
3.心得/評論:
好久沒有合一的消息了,最近的合一很溫順
外資連買了好幾天 明天電梯向??
※必需填寫滿20字
--
1.發文前請先詳閱[新聞]分類發文規範,未依規範發文將受處份。
2.連結過長請善用 https://goo.gl/ 縮網址,連結能不能點擊者板規1-2-2處份。
3.心得/評論請盡量充實,心得過短或濫竽充數將會以1-2-3&一行文規範水桶處份。
---------------------------按ctrl+y可刪除以上內容。----------------------
1.原文連結:https://reurl.cc/ygZmyE
※過長無法點擊者必須縮網址
2.原文內容:
1.產品內容:Anti-IL6全人單株抗體新藥FB704A
2.產品量產日期:NA
3.對公司財務、業務之影響:
(1)研發新藥名稱或代號:FB704A。
(2)用途:中和IL6之全人源單株抗體新藥,治療因IL6引起之相關疾病。
臨床試驗資訊網址:https://clinicaltrials.gov/ct2/show/NCT03890302
(3)預計進行之所有研發階段:探索性二期臨床試驗/二期臨床試驗/三期臨床試驗及
新藥查驗登記。
(4)目前進行中之研發階段:第一期臨床試驗。(Ia+Ib)
A.各期人體臨床試驗(含期中分析)結果:
(A)臨床試驗設計介紹
a.試驗計畫名稱:評估FB704A單次和多次遞增劑量的安全性,耐受性,藥
物動力學、和臨床活性之第一期、隨機,安慰劑對照,雙盲臨床試驗。
b.試驗目的:於美國執行單一中心、隨機分派、對照組控制之一期臨床試
驗,評估FB704A針對健康受試者及類風濕性關節炎病人之安全性、耐受
性、藥物動力及臨床活性。
c.試驗階段分級:第一期臨床試驗。
d.藥品名稱:FB704A。
e.宣稱適應症:類風濕性關節炎。
f.評估指標
(a)主要評估指標:FB704A之安全性、耐受性
(b)次要評估指標:藥物動力學 (Pharmacokinetics;PK)、免疫原性
(Immunogenicity)、生物標記 (包括:IL-6、CRP及ESR)、關節炎活
動度(DAS28-CRP, TJC 及 SJC)。
g.試驗計畫受試者收納人數:健康受試者25人,類風濕性關節炎患者最多
16人。
(B)主要及次要評估指標之統計結果及統計上之意義:
本公司抗IL6抗體新藥FB704A一期臨床試驗,共收納健康受試者25人,類
風濕性關節炎患者6人,各項臨床試驗指標結果如下:
a.主要評估指標:FB704A之安全性、耐受性
(a)試驗結果顯示,在使用至8 mg/kg的最高劑量下,FB704A無論在健康
受試者或類風濕性關節炎病患,皆具有良好的安全性與耐受性。在
納入試驗的25位健康受試者與6位類風濕關節炎受試者中,皆無藥物
相關的嚴重不良反應(SAE)發生。所有不良反應(AEs)皆為二級以下,
並且在試驗結束後皆已緩解。主要藥物相關不良反應包括白血球與中
性顆粒球降低,為IL6抗體藥物常見之不良反應。
(b)所有受試者的臨床實驗室檢查(血液學、凝血功能、血清化學、肝功
能及尿液檢查)、生命體徵測量(收縮壓、舒張壓、心跳速率、呼吸
速率及口溫)、12導聯心電圖、心電遙測和理學檢查結果,皆顯示
FB704A未造成不良影響。
(c)FB704A的最大耐受劑量 (MTD)為 > 8 mg/kg。
b.次要評估指標:
(a)藥物動力學 (Pharmacokinetics;PK):
在健康受試者,分別靜脈輸注投予一劑0.5, 2, 4, 8 mg/kg的FB704A
後,最高血中藥物濃度(Cmax)、時間零至最終採血點時間之曲線下總
面積(AUC0-t)與時間零至無限大之曲線下總面積(AUC0-∞),皆隨劑
量增加而增加,且生體半衰期長達約14天,結果顯示FB704A具有良好
的藥動學特性。
此外,類風濕性關節炎病人每兩周投予一劑2 mg/kg的FB704A,連續
投予4劑的結果顯示,與健康受試者具有相似的藥動學特性,且無顯
著蓄積性。上述結果有助於未來二期臨床試驗之設計及規劃。
(b)免疫原性(immunogenicity):
FB704A給藥組皆未產生FB704A的自體抗體,初步顯示FB704A的低免疫
原性。
(c)生物標記:
(i)IL6:RA病人給予FB704A前血液中的IL6濃度為255.98±504.89pg/ml
,而給予四劑FB704A後,血中IL6濃度增加為1205.38±437.16pg/ml
,顯示FB704A有效結合血中IL6,使IL6被FB704A捕獲而累積於血
液中。
(ii)CRP: CRP為發炎反應以及類風濕性關節炎的重要指標,病患給予
FB704A後平均CRP數值下降60.9%,高於安慰劑組的35.7%,初步
驗證FB704A於RA病人產生的藥效。
(iii)ESR:ESR為紅血球沉降速率,本試驗尚未觀察到變化趨勢。
(d)關節炎活動度 (DAS28-CRP,TJC及SJC):
由於受試病患族群少且治療時間較短,本試驗尚未觀察到變化趨勢。
(C)單一臨床試驗結果,並不足以充分反映未來新藥開發上市之成敗,投資人
應審慎判斷謹慎投資。
B.未通過目的事業主管機關許可者,公司所面臨之風險及因應措施:不適用。
C.已通過目的事業主管機關許可者,未來經營方向:不適用。
D.已投入之累積研發費用:考量未來市場行銷策略,為保障公司及投資人權益,
故不予公開揭露。
(5)將再進行之下一研發階段:探索性二期臨床試驗/二期臨床試驗
A.預計完成時間:依據一期臨床試驗之結果,積極設計探索性二期臨床試驗,預計
2021年可完成此試驗。
B.預計應負擔之義務:不適用。
(6)市場現況:
FB704A完成一期臨床試驗,除獲得完整藥動學參數外,並初步驗證其安全性與人體
藥理活性,由於IL6相關疾病的適應症廣泛,本公司正積極評估以下具市場潛力的
適應症:
A.全身性硬化症及其肺部纖維化機制與IL-6作用相關,全球約有2.7 million病人
,2026年全球藥物市場預估為38億美金(globe newswire),過往多透過免疫調
節、類固醇與抗發炎等藥物來減少全身性硬化症的惡化,新上市藥物也僅能改
善肺功能,未能有效阻止皮膚症狀的惡化,目前全身性硬化症未有生物製劑上
市。
B.氣喘藥物全球市場2027年將達到260.1億美金(globe newswire) ,病人數上看
33.4 million,嚴重氣喘族群雖僅佔10% 氣喘病人數,卻佔據了50%以上的醫療
花費,其中復發率高且難以控制的嚴重嗜中球性氣喘 (neutrophilic asthma)
,致病機轉與IL-6相關,該病症目前已上市藥物皆無法有效控制,為目前未被
滿足的醫療需求。
4.其他應敘明事項:
(1)依據財團法人中華民國證券櫃檯買賣中心之「上(興)櫃公司重大訊息發布應注意事
項參考問答集」第二項規範:「新藥研發公司取得各期人體臨床試驗評估指標之統
計結果時,即時發布重大訊息。
(2)新藥開發時程長、投入經費高且並未保證一定能成功,此等可能使投資面臨風險,
投資人應審慎判斷謹慎投資。
3.心得/評論:
好久沒有合一的消息了,最近的合一很溫順
外資連買了好幾天 明天電梯向??
※必需填寫滿20字
--
Tags:
股票
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at 2020-09-28T06:24
at 2020-09-28T06:24
By Thomas
at 2020-09-30T15:51
at 2020-09-30T15:51
By Callum
at 2020-10-01T08:12
at 2020-10-01T08:12
By Joseph
at 2020-10-06T03:32
at 2020-10-06T03:32
By Anthony
at 2020-10-09T07:51
at 2020-10-09T07:51
By Enid
at 2020-10-11T22:29
at 2020-10-11T22:29
By Dinah
at 2020-10-13T14:04
at 2020-10-13T14:04
By Lucy
at 2020-10-14T21:41
at 2020-10-14T21:41
By Zenobia
at 2020-10-19T18:06
at 2020-10-19T18:06
By Charlotte
at 2020-10-20T18:56
at 2020-10-20T18:56
By Megan
at 2020-10-21T10:00
at 2020-10-21T10:00
By Edward Lewis
at 2020-10-21T12:39
at 2020-10-21T12:39
By Ingrid
at 2020-10-23T10:27
at 2020-10-23T10:27
By Robert
at 2020-10-25T16:49
at 2020-10-25T16:49
By Ethan
at 2020-10-28T12:16
at 2020-10-28T12:16
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at 2020-11-02T03:09
at 2020-11-02T03:09
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at 2020-11-06T04:08
at 2020-11-06T04:08
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at 2020-11-10T04:46
at 2020-11-10T04:46
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at 2020-11-10T19:22
at 2020-11-10T19:22
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at 2020-11-14T07:58
at 2020-11-14T07:58
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at 2020-11-17T03:39
at 2020-11-17T03:39
By Barb Cronin
at 2020-11-18T09:55
at 2020-11-18T09:55
By Gary
at 2020-11-21T06:14
at 2020-11-21T06:14
By Rebecca
at 2020-11-25T16:49
at 2020-11-25T16:49
By Margaret
at 2020-11-27T23:22
at 2020-11-27T23:22
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at 2020-11-29T02:32
at 2020-11-29T02:32
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at 2020-11-30T11:27
at 2020-11-30T11:27
By Ophelia
at 2020-12-01T14:35
at 2020-12-01T14:35
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at 2020-12-01T20:50
at 2020-12-01T20:50
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at 2020-12-05T12:59
at 2020-12-05T12:59
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at 2020-12-07T10:14
at 2020-12-07T10:14
By Connor
at 2020-12-09T10:58
at 2020-12-09T10:58
By Regina
at 2020-12-14T02:26
at 2020-12-14T02:26
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at 2020-12-18T07:51
at 2020-12-18T07:51
By Kama
at 2020-12-21T14:10
at 2020-12-21T14:10
By Mary
at 2020-12-24T18:38
at 2020-12-24T18:38
By Anonymous
at 2020-12-24T21:48
at 2020-12-24T21:48
By Candice
at 2020-12-26T08:20
at 2020-12-26T08:20
By David
at 2020-12-30T18:39
at 2020-12-30T18:39
By Odelette
at 2021-01-02T11:05
at 2021-01-02T11:05
By Kyle
at 2021-01-06T10:43
at 2021-01-06T10:43
By Hardy
at 2021-01-10T14:08
at 2021-01-10T14:08
By Callum
at 2021-01-11T00:20
at 2021-01-11T00:20
By Eden
at 2021-01-11T14:23
at 2021-01-11T14:23
By Iris
at 2021-01-14T15:18
at 2021-01-14T15:18
By Damian
at 2021-01-15T18:35
at 2021-01-15T18:35
By Brianna
at 2021-01-16T06:50
at 2021-01-16T06:50
By Queena
at 2021-01-17T00:30
at 2021-01-17T00:30
By Victoria
at 2021-01-18T15:37
at 2021-01-18T15:37
By Audriana
at 2021-01-22T20:41
at 2021-01-22T20:41
By Suhail Hany
at 2021-01-25T12:33
at 2021-01-25T12:33
By Noah
at 2021-01-28T02:56
at 2021-01-28T02:56
By Charlie
at 2021-01-29T17:18
at 2021-01-29T17:18
By Valerie
at 2021-02-02T19:56
at 2021-02-02T19:56
By James
at 2021-02-06T10:36
at 2021-02-06T10:36
By Donna
at 2021-02-10T20:50
at 2021-02-10T20:50
By Kyle
at 2021-02-12T12:19
at 2021-02-12T12:19
By Damian
at 2021-02-16T18:01
at 2021-02-16T18:01
By Charlie
at 2021-02-20T20:59
at 2021-02-20T20:59
By Sandy
at 2021-02-21T17:34
at 2021-02-21T17:34
By Thomas
at 2021-02-25T10:48
at 2021-02-25T10:48
By Rebecca
at 2021-02-28T05:15
at 2021-02-28T05:15
By Freda
at 2021-03-03T09:50
at 2021-03-03T09:50
By Isla
at 2021-03-03T23:30
at 2021-03-03T23:30
By Barb Cronin
at 2021-03-05T19:50
at 2021-03-05T19:50
By William
at 2021-03-06T01:39
at 2021-03-06T01:39
By Lily
at 2021-03-07T15:38
at 2021-03-07T15:38
By Susan
at 2021-03-09T02:41
at 2021-03-09T02:41
By Xanthe
at 2021-03-11T01:01
at 2021-03-11T01:01
By Catherine
at 2021-03-13T07:52
at 2021-03-13T07:52
By Delia
at 2021-03-15T02:12
at 2021-03-15T02:12
By Jacob
at 2021-03-18T05:43
at 2021-03-18T05:43
By Necoo
at 2021-03-21T06:18
at 2021-03-21T06:18
By Regina
at 2021-03-25T14:13
at 2021-03-25T14:13
By Caitlin
at 2021-03-26T09:42
at 2021-03-26T09:42
By Tom
at 2021-03-28T04:32
at 2021-03-28T04:32
By Ida
at 2021-03-30T19:29
at 2021-03-30T19:29
By Dorothy
at 2021-04-01T00:52
at 2021-04-01T00:52
By Annie
at 2021-04-01T11:53
at 2021-04-01T11:53
By Hedda
at 2021-04-05T15:55
at 2021-04-05T15:55
By Odelette
at 2021-04-10T03:02
at 2021-04-10T03:02
By Oliver
at 2021-04-14T19:26
at 2021-04-14T19:26
By Lauren
at 2021-04-15T03:08
at 2021-04-15T03:08
By Gary
at 2021-04-17T23:27
at 2021-04-17T23:27
By Ida
at 2021-04-18T06:42
at 2021-04-18T06:42
By Xanthe
at 2021-04-21T01:12
at 2021-04-21T01:12
By Mia
at 2021-04-21T04:57
at 2021-04-21T04:57
By Queena
at 2021-04-21T16:06
at 2021-04-21T16:06
By Vanessa
at 2021-04-23T00:01
at 2021-04-23T00:01
By Isabella
at 2021-04-24T07:20
at 2021-04-24T07:20
By Ingrid
at 2021-04-24T15:53
at 2021-04-24T15:53
By Donna
at 2021-04-25T15:49
at 2021-04-25T15:49
By John
at 2021-04-28T10:14
at 2021-04-28T10:14
By Olga
at 2021-05-02T00:39
at 2021-05-02T00:39
By Blanche
at 2021-05-04T00:13
at 2021-05-04T00:13
By Blanche
at 2021-05-05T16:03
at 2021-05-05T16:03
By Liam
at 2021-05-09T09:27
at 2021-05-09T09:27
By Liam
at 2021-05-12T19:20
at 2021-05-12T19:20
By Quintina
at 2021-05-13T11:41
at 2021-05-13T11:41
By Vanessa
at 2021-05-17T00:31
at 2021-05-17T00:31
By Margaret
at 2021-05-21T21:27
at 2021-05-21T21:27
By Carolina Franco
at 2021-05-23T12:43
at 2021-05-23T12:43
By Edith
at 2021-05-27T00:32
at 2021-05-27T00:32
By Puput
at 2021-05-30T07:21
at 2021-05-30T07:21
By Sierra Rose
at 2021-06-01T15:42
at 2021-06-01T15:42
By Sierra Rose
at 2021-06-04T19:01
at 2021-06-04T19:01
By Andrew
at 2021-06-08T03:53
at 2021-06-08T03:53
By Andy
at 2021-06-08T10:07
at 2021-06-08T10:07
By Xanthe
at 2021-06-09T22:01
at 2021-06-09T22:01
By Bennie
at 2021-06-11T05:30
at 2021-06-11T05:30
By Kumar
at 2021-06-16T05:24
at 2021-06-16T05:24
By Yuri
at 2021-06-19T04:31
at 2021-06-19T04:31
By Annie
at 2021-06-19T23:45
at 2021-06-19T23:45
By Donna
at 2021-06-22T08:55
at 2021-06-22T08:55
By Aaliyah
at 2021-06-26T22:13
at 2021-06-26T22:13
By David
at 2021-07-01T01:17
at 2021-07-01T01:17
By Anonymous
at 2021-07-03T14:49
at 2021-07-03T14:49
By Yedda
at 2021-07-04T05:46
at 2021-07-04T05:46
By Ida
at 2021-07-05T02:59
at 2021-07-05T02:59
By John
at 2021-07-06T22:35
at 2021-07-06T22:35
By Eden
at 2021-07-08T08:28
at 2021-07-08T08:28
By Todd Johnson
at 2021-07-12T05:40
at 2021-07-12T05:40
By Jacky
at 2021-07-15T15:42
at 2021-07-15T15:42
By Freda
at 2021-07-16T13:15
at 2021-07-16T13:15
By Tristan Cohan
at 2021-07-19T16:15
at 2021-07-19T16:15
By Zora
at 2021-07-21T15:26
at 2021-07-21T15:26
By Carolina Franco
at 2021-07-24T12:04
at 2021-07-24T12:04
By Charlotte
at 2021-07-29T03:02
at 2021-07-29T03:02
By Wallis
at 2021-08-01T12:15
at 2021-08-01T12:15
By Genevieve
at 2021-08-03T04:39
at 2021-08-03T04:39
By Elizabeth
at 2021-08-06T17:09
at 2021-08-06T17:09
By Quanna
at 2021-08-11T06:54
at 2021-08-11T06:54
By Michael
at 2021-08-14T09:09
at 2021-08-14T09:09
By Emily
at 2021-08-18T12:11
at 2021-08-18T12:11
By Valerie
at 2021-08-22T02:01
at 2021-08-22T02:01
By James
at 2021-08-23T07:41
at 2021-08-23T07:41
By Connor
at 2021-08-27T07:39
at 2021-08-27T07:39
By Quintina
at 2021-08-30T21:37
at 2021-08-30T21:37
By Zenobia
at 2021-09-03T18:06
at 2021-09-03T18:06
By Dinah
at 2021-09-03T19:38
at 2021-09-03T19:38
By Quanna
at 2021-09-07T17:00
at 2021-09-07T17:00
By Damian
at 2021-09-10T06:26
at 2021-09-10T06:26
By Ida
at 2021-09-14T07:31
at 2021-09-14T07:31
By Gary
at 2021-09-18T18:23
at 2021-09-18T18:23
By Brianna
at 2021-09-22T05:52
at 2021-09-22T05:52
By Cara
at 2021-09-23T16:56
at 2021-09-23T16:56
By Andrew
at 2021-09-26T20:41
at 2021-09-26T20:41
By Hedy
at 2021-10-01T04:30
at 2021-10-01T04:30
By Blanche
at 2021-10-04T15:36
at 2021-10-04T15:36
By Dora
at 2021-10-07T08:03
at 2021-10-07T08:03
By Elma
at 2021-10-09T21:43
at 2021-10-09T21:43
By Rachel
at 2021-10-10T13:46
at 2021-10-10T13:46
By Victoria
at 2021-10-10T18:03
at 2021-10-10T18:03
By Odelette
at 2021-10-12T21:49
at 2021-10-12T21:49
By Oscar
at 2021-10-15T21:24
at 2021-10-15T21:24
By Blanche
at 2021-10-17T21:14
at 2021-10-17T21:14
By Joseph
at 2021-10-19T11:04
at 2021-10-19T11:04
By Emily
at 2021-10-23T01:09
at 2021-10-23T01:09
By Adele
at 2021-10-26T18:47
at 2021-10-26T18:47
By Yuri
at 2021-10-27T17:39
at 2021-10-27T17:39
By Ursula
at 2021-10-29T03:41
at 2021-10-29T03:41
By Mia
at 2021-11-01T17:54
at 2021-11-01T17:54
By Lucy
at 2021-11-02T08:04
at 2021-11-02T08:04
By Ursula
at 2021-11-04T11:14
at 2021-11-04T11:14
By Odelette
at 2021-11-05T01:09
at 2021-11-05T01:09
By Edward Lewis
at 2021-11-05T07:42
at 2021-11-05T07:42
By Ivy
at 2021-11-08T12:24
at 2021-11-08T12:24
By Edwina
at 2021-11-13T09:07
at 2021-11-13T09:07
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at 2021-11-16T11:45
at 2021-11-16T11:45
By Elizabeth
at 2021-11-18T02:11
at 2021-11-18T02:11
By Zora
at 2021-11-20T22:18
at 2021-11-20T22:18
By Bethany
at 2021-11-22T07:46
at 2021-11-22T07:46
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at 2021-11-23T15:59
at 2021-11-23T15:59
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at 2021-11-25T05:45
at 2021-11-25T05:45
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at 2021-11-25T11:25
at 2021-11-25T11:25
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at 2021-11-27T18:34
at 2021-11-27T18:34
By Robert
at 2021-11-29T07:50
at 2021-11-29T07:50
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at 2021-12-02T05:08
at 2021-12-02T05:08
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at 2021-12-03T11:48
at 2021-12-03T11:48
By Liam
at 2021-12-04T01:00
at 2021-12-04T01:00
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at 2021-12-05T17:31
at 2021-12-05T17:31
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at 2021-12-10T15:40
at 2021-12-10T15:40
By Dorothy
at 2021-12-13T19:03
at 2021-12-13T19:03
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at 2021-12-18T01:50
at 2021-12-18T01:50
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at 2021-12-19T17:28
at 2021-12-19T17:28
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at 2021-12-24T02:30
at 2021-12-24T02:30
By Susan
at 2021-12-27T01:54
at 2021-12-27T01:54
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at 2021-12-29T15:56
at 2021-12-29T15:56
By Madame
at 2022-01-03T00:11
at 2022-01-03T00:11
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at 2022-01-07T17:02
at 2022-01-07T17:02
By Hazel
at 2022-01-08T06:06
at 2022-01-08T06:06
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at 2022-01-08T19:21
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at 2022-01-10T19:44
at 2022-01-10T19:44
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at 2022-01-13T20:49
at 2022-01-13T20:49
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at 2022-01-16T07:21
at 2022-01-16T07:21
By Andy
at 2022-01-17T02:24
at 2022-01-17T02:24
By Heather
at 2022-01-18T01:34
at 2022-01-18T01:34
By Zanna
at 2022-01-20T19:24
at 2022-01-20T19:24
By Anthony
at 2022-01-24T01:36
at 2022-01-24T01:36
By Odelette
at 2022-01-24T04:11
at 2022-01-24T04:11
By Lucy
at 2022-01-28T17:23
at 2022-01-28T17:23
By Sandy
at 2022-01-30T01:00
at 2022-01-30T01:00
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at 2022-02-02T08:48
at 2022-02-02T08:48
By Todd Johnson
at 2022-02-06T08:43
at 2022-02-06T08:43
By Hazel
at 2022-02-09T09:20
at 2022-02-09T09:20
By Ida
at 2022-02-11T07:09
at 2022-02-11T07:09
By Ingrid
at 2022-02-13T03:51
at 2022-02-13T03:51
By Agnes
at 2022-02-15T09:38
at 2022-02-15T09:38
By Yedda
at 2022-02-17T03:37
at 2022-02-17T03:37
By Rachel
at 2022-02-18T03:08
at 2022-02-18T03:08
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at 2022-02-20T06:39
at 2022-02-20T06:39
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at 2022-02-24T09:01
at 2022-02-24T09:01
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at 2022-02-28T05:09
at 2022-02-28T05:09
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at 2022-03-03T09:32
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at 2022-03-09T20:52
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at 2022-03-13T14:08
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at 2022-03-18T12:45
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at 2022-03-26T02:00
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at 2022-03-30T12:29
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at 2022-04-04T11:41
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at 2022-04-05T03:22
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at 2022-04-07T08:47
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at 2022-04-21T11:46
at 2022-04-21T11:46
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at 2022-04-23T20:10
at 2022-04-23T20:10
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at 2022-04-25T19:56
at 2022-04-25T19:56
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at 2022-04-30T13:30
at 2022-04-30T13:30
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at 2022-05-04T04:42
at 2022-05-04T04:42
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at 2022-05-08T23:35
at 2022-05-08T23:35
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at 2022-05-09T15:15
at 2022-05-09T15:15
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at 2022-05-14T03:22
at 2022-05-14T03:22
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at 2022-05-18T10:48
at 2022-05-18T10:48
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at 2022-05-18T16:37
at 2022-05-18T16:37
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at 2022-05-20T05:54
at 2022-05-20T05:54
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at 2022-05-21T08:04
at 2022-05-21T08:04
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at 2022-05-25T20:49
at 2022-05-25T20:49
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at 2022-05-28T04:15
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at 2022-06-01T14:31
at 2022-06-01T14:31
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at 2022-06-05T16:51
at 2022-06-05T16:51
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at 2022-06-06T23:54
at 2022-06-06T23:54
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at 2022-06-11T14:09
at 2022-06-11T14:09
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at 2022-06-14T00:41
at 2022-06-14T00:41
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at 2022-06-18T00:50
at 2022-06-18T00:50
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at 2022-06-21T00:39
at 2022-06-21T00:39
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at 2022-06-24T12:11
at 2022-06-24T12:11
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at 2022-06-28T02:14
at 2022-06-28T02:14
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at 2022-07-02T13:36
at 2022-07-02T13:36
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at 2022-07-03T01:34
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at 2022-07-03T06:47
at 2022-07-03T06:47
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at 2022-07-07T17:31
at 2022-07-07T17:31
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at 2022-07-11T17:09
at 2022-07-11T17:09
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